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Unit 1 - Resistance of Pathogens to Antibiotics (H)

In centuries past, millions of people died because of diseases spread by pathogens. Two scientific discoveries have helped to prevent the vast majority of these deaths - vaccines and antibiotics. Today we face a new threat - strains of bacteria which have formed a resistance to antibiotics. This GCSE Biology quiz looks at some of these bacteria, how they spread and what we can do to stop them.

Pathogens include bacteria, viruses and fungi which are capable of causing diseases. Alexander Fleming discovered penicillin in 1928, but it took 12 more years until a method was found that could be used to produce it in sufficient quantities to be used in hospitals. It came in time to save the lives of many WWII soldiers who would have otherwise died because their wounds became infected. Since penicillin, scientists have developed many other antibiotics to target certain types of pathogens - namely, specific strains of bacteria. Antibiotics do not destroy viruses or fungi.

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In recent times, antibiotic-resistant strains of bacteria have appeared which pose a threat to human health as they are very difficult to kill. The usual example of this is the MRSA bacterium in hospitals. This has developed a resistance to antibiotics but can be controlled by good hygiene - visitors to hospital wards are required to use a special alcohol based hand cleanser when entering and leaving a ward and regular use of bleach or other disinfectants when cleaning hospitals keep this dangerous bacterium under control.

But how do these resistant strains of bacteria arise? Firstly, there is the overuse of antibiotics. At one time, doctors would prescribe antibiotics 'just in case'. In other words, if a patient did not show signs of having a bacterial infection, they would still prescribe antibiotics to prevent infection. This allowed bacteria plenty of opportunity to mutate and develop a resistance.

Secondly, a course of antibiotics usually lasts from 7 - 10 days. Normally by day 3 or 4, you start to feel a lot better as the majority of the bacteria have been killed and some people then stop taking them. But the most resistant bacteria are still in your system and the rest of the course is designed to kill as many of these as possible leaving the remaining bacteria to be killed by your own immune system. Stopping taking a course of antibiotics early leaves too many of these resistant bacteria for your system to fully destroy and they can then be passed on to other people.

This quiz addresses the higher tier content of Unit 1.

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  1. How have we slowed down the spread of antibiotic-resistant bacteria?
    Resistant strains are encouraged to develop by the overuse of antibiotics
  2. How have doctors tried to reduce antibiotic resistance?
    Doctors prescribe antibiotics only when the body has not been able to fight off a bacterial infection on its own
  3. What do we call individual pathogens which antibiotics can kill?
    Antibiotics are designed to kill bacteria only but some will kill infections of single celled parasites like Giardia
  4. Which of the following would be the usual medical advice for a sore throat?
    Honey can help soothe a sore throat, your immune system deals with the infection
  5. What does MRSA stand for?
    Soap and water, alcohol based hand gels and bleach can all destroy this dangerous bacteria
  6. Antibiotic resistance can lead to what?
    Dangerous strains of bacteria are possible due to antibiotic resistance
  7. Why can it be dangerous if you do not complete your course of antibiotics?
    Resistant bacteria cannot be killed using antibiotics
  8. Individual pathogens survive, reproduce and can form new strains by which process?
    Bacteria reproduce rapidly. Amongst the new generations, there will be some bacteria whose genes have mutated - natural selection does the rest
  9. Resistance to antibiotics in bacteria is controlled by what?
    Scientists are constantly developing new antibiotics to deal with these resistant strains of bacteria
  10. Antibiotic-resistant strains of bacteria spread quickly. Why is this?
    It is for this reason that antibiotics should only be prescribed when absolutely necessary - the fewer strains of resistant bacteria, the better

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